GEO series
mRNA juxtacap sequences govern mRNA translation and stability
GSE188510
Homo sapiens
Expression profiling by high throughput sequencing
40 samples
2024/12/04
GPL24676GPL20795
Summary
Here we utilize a highly precise transcription-start site (TSS) mapping method to assess the relative contributions of the first transcribed nucleotides and modifications (the "juxtacap") to mRNA stability and translation. We find that several functionally relevant juxtacaps exist, and the presence of m6Am regulates the effect of adenosine juxtacaps.
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Paper (PMID 39677659) ↗
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