GEO series
Human FcgRIIa mediates attenuation of IFN-I response in human monocytes
GSE190623
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2024/12/10
GPL23227
Summary
It is generally believed that there is continued cross-regulation between adaptive humoral immunity and Type I interferon (IFN-I) response during viral infections, but the question how antibodies (Abs), and/or Ab-antigen immunocomplexes (ICs), regulate IFN-I production and/or signaling in immune cells remains unanswered. Here we report that plate-coated IgG (cIgG), a mimic IC without antigen restriction, could dampen IFN-I signaling in monocytes through FcgRIIa.
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