GEO series
TTFields plus TMZ treatment effects on newly diagnosed Glioblastoma patients in peripheral blood
GSE193525
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2025/01/01
GPL24676
Summary
We report the application of single-cell-RNA-based sequencing technology for high-throughput profiling of peripheral blood mononuclear cells. By sequencing in total of 193,760 PBMCs in 12 GBM patients, we generated an overview of patient peripheral immune status with 38 biologically recongnized cell subtypes. By paired comparing pre- and post- treatment samples, we find a robust post-TTFields activation of adaptive immunity via the T1IFN trajectory anchored by plasmacytoid DCs. This study provides a framework for the application of scRNAseq towards characterization of peripheral immune activation status.
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