RNA sequencing of ovarian cancer cells treated by Paeonol

Traditional Chinese medicine (TCM) is widely used in clinics because of its beneficial features including multi-target effects, lower side effects, and safety, among which the anti-tumor effect has sparked wide attention. Paeonol (Pae; 2’-hydroxy-4’-methoxyacetophenone), a phenolic acid compound derived from the root bark of the Moutan Cortex, possesses properties with anti-inflammatory, antioxidant, immune regulatory activity and reverse chemoresistance, has been regarded as a potential anti-tumor drug. Our previous study have revealed that Pae activates autophagy by inhibiting the Akt/mTOR signaling pathway, suppressing the proliferation and inducing apoptosis in OC cells in a concentration- and time-dependent manner. Recently Pae was found to ameliorate glucose and lipid metabolism disorders in diabetic mice and improve acetylation of HK39 and HK412 through decreasing the expression of histone deacetylases. However, the detailed mechanism relevant for anti-tumor effects of Pae in EOC need to be explored.