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3D chromatin architecture of drug-tolerant cancer cells at single-cell resolution (Reference dataset of population cells)

GSE195810 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/08/14 Platform GPL21290
Summary
Anticancer drug therapy generally elicits the drug tolerance after long-term treatment. Recent studies suggested that 3D chromatin structures of cancer cells were intimately linked to drug resistance. However, 3D chromatin structures in drug-tolerant cancer cells at single-cell resolution haven’t been elucidated. Here we performed single-cell Hi-C (scHi-C) analysis to examine the 3D chromatin structures in three stages of breast cancer cells. Population cells Hi-C data as the reference.
Published in
Integration of scHi-C and scRNA-seq data defines distinct 3D-regulated and biological-context dependent cell subpopulations
Zhou Y, Li T, Choppavarapu L et al. · Nature communications 2024 · PMID 39333113 · doi:10.1038/s41467-024-52440-0
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Direct links to NCBI, no account and no request form: the whole study as GSE195810_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA802208 and SRA study SRP357578. Searching any of these in the dataset finder brings you back here.

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