GEO series
Targeting S6K1 and S6K2 by siRNA and sgRNA in LN229 GBM cells
GSE196591
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2024/08/28
GPL21697
Summary
To systematically identify the function of S6K1 and S6K2 in glioblastoma cells, LN229 cells were stably transduced with Cas9, control non-targeting sgRNA (sgNT), or sgRNAs targeting S6K1 or S6K2. The cells were then transiently transfected with non-targeting siRNAs (siNT), or siRNA pools targeting S6K1 or S6K2. RNA sequencing was performed to compare cellular responses to inactivation of single or combination S6 kinases.
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Paper (PMID 39087397) ↗
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