← BioTransfer GEO Dataset Finder
GEO series

An epigenetic gene signature underlies phenotype switching in early stage melanomas [YUCHIME]

GSE198427 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/08 Platform GPL18573
Summary
A 122-epigenetic gene signature distinguished low- versus high-risk early stage melanomas. We sought to validate the signature, examined clinical correlates in a cohort of primary melanomas of the skin, and studied the underlying transcriptomic aberrations and changes in chromatin in cell lines representing these two groups.
Published in
Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation
Mendelson K, Martin TC, Nguyen CB et al. · JCI insight 2024 · PMID 38319712 · doi:10.1172/jci.insight.166611
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE198427_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA815290 and SRA study SRP363602. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.