GEO series
Inhibition of histone acetyltransferase attenuates 3D chromatin-mediated insulin signaling in pancreatic cancer (RNAseq dataset)
GSE198444
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2024/06/10
GPL21290
Summary
Inhibition of histone acetyltransferase has been widely used to be effectively treat cancers in many studies. However, it’s not clear how the downstream signaling responds to the inhibitor in pancreatic cancer. Here we performed Hi-C experiments and RNA-seq to canonical and patient-derived pancreatic cancer cells with the treatment of small molecule inhibitor ICG-001 which has dual function to block both WNT signaling and histone acetyltransferase. This is RNA-seq dataset.
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Paper (PMID 38927910) ↗
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