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PEAR1 is a potential regulator of early hematopoiesis of human pluripotent stem cells

GSE198739 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/30 Platform GPL24676
Summary
Human pluripotent stem cells (hPSCs) provide a potential resource for the generation of functional blood cells in vitro. However, it remains largely unknown about the mechanism underlying hPSC-derived hematopoiesis. Here, we identified platelet endothelial aggregation receptor-1 (PEAR1) as a potential regulator of early hematopoietic development of hPSCs. We found that the expression of PEAR1 was gradually increased during endothelial and hematopoietic development. The hematopoietic potential was enriched in PEAR1+ population and PEAR1 could be used as a potential marker to enrich hemogenic endothelium. Moreover, knockout of PEAR1 impaired the hematopoietic potential of hPSCs. Collectively, our findings demonstrate that PEAR1 is required for early hematopoiesis and can be potentially used for establishing new strategies to produce more functional blood cells from hPSCs.
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Also filed as BioProject PRJNA816717 and SRA study SRP364280. Searching any of these in the dataset finder brings you back here.

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