The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice

To compare gene expression between the materal X (Xm) and paternal X (Xp), we used a flurorescence-based cell sorting to separate the maternal X from the paternal X. Then we performed gene expression analysis using data obtained from RNA-seq of young Xm and Xp cells To compare gene expression between the materal X (Xm) and paternal X (Xp) in neurons from both young and old mice, we used a flurorescence-based cell sorting to separate the maternal X from the paternal X. Then we performed gene expression analysis using data obtained from RNA-seq of young and old Xm and Xp neurons.