Receptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 64 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 64 samples: 56 distinct titles, 8 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Direct targeting and regulation of RNA polymerase II by cell signaling kinasesScience (New York, N.Y.) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE202761_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA837229 and SRA study SRP374761. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 64 sample titles: 56 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6132702 ChIPseq_2230546_DMSO_Input
- GSM6132703 ChIPseq_2230547_DMSO_IgG
- GSM6132704 ChIPseq_2230548_DMSO_pY1
- GSM6132705 ChIPseq_2230549_DMSO_pEGFR_Abcm
- GSM6132706 ChIPseq_2230550_DMSO_pEGFR_CS
- GSM6132707 ChIPseq_2230551_EGF_Input
- GSM6132708 ChIPseq_2230552_EGF_IgG
- GSM6132709 ChIPseq_2230553_EGF_pY1
- GSM6132710 ChIPseq_2230554_EGF_pEGFR_Abcm
- GSM6132711 ChIPseq_2230555_EGF_pEGFR_CS
- GSM6132712 ChIPseq_2230556_Erlotinib_Input
- GSM6132713 ChIPseq_2230557_Erlotinib_IgG
- GSM6132714 ChIPseq_2230558_Erlotinib_pY1
- GSM6132715 ChIPseq_2230559_Erlotinib_pEGFR_Abcm
- GSM6132716 ChIPseq_2230560_Erlotinib_pEGFR_CS
- GSM6132717 ChIPseq_2230561_Erlotinib_EGF_Input
- GSM6132718 ChIPseq_2230562_Erlotinib_EGF_IgG
- GSM6132719 ChIPseq_2230563_Erlotinib_EGF_pY1
- GSM6132720 ChIPseq_2230564_Erlotinib_EGF_pEGFR_Abcm
- GSM6132721 ChIPseq_2230565_Erlotinib_EGF_pEGFR_CS
- GSM6132722 ChIPseq_2250341_ChIP02_DMSO_pY1
- GSM6132723 ChIPseq_2250342_ChIP02_EGF_pY1
- GSM6132724 ChIPseq_2250343_ChIP02_Erlotinib_pY1
- GSM6132725 ChIPseq_2250344_ChIP02_Erlotinib_EGF_pY1
- GSM6132726 ChIPseq_2250345_ChIP02_DMSO_pEGFR_CS
- GSM6132727 ChIPseq_2250346_ChIP02_EGF_pEGFR_CS
- GSM6132728 ChIPseq_2250347_ChIP02_Erlotinib_pEGFR_CS
- GSM6132729 ChIPseq_2250348_ChIP02_Erlotinib_EGF_pEGFR_CS
- GSM6132730 ChIPseq_2250349_ChIP02_DMSO_pEGFR_Ab
- GSM6132731 ChIPseq_2250350_ChIP02_EGF_pEGFR_Ab
- GSM6132732 ChIPseq_2250351_ChIP02_Erlotinib_pEGFR_Ab
- GSM6132733 ChIPseq_2250352_ChIP02_Erlotinib_EGF_pEGFR_Ab
- GSM6132734 ChIPseq_2250353_ChIP02_DMSO_Input
- GSM6132735 ChIPseq_2250354_ChIP02_EGF_Input
- GSM6132736 ChIPseq_2250355_ChIP02_Erlotinib_Input
- GSM6132737 ChIPseq_2250356_ChIP02_Erlotinib_EGF_Input
- GSM6132738 ChIPseq_2281748_ChIP03_DMSO_pY1
- GSM6132739 ChIPseq_2281749_ChIP03_EGF_pY1
- GSM6132740 ChIPseq_2281750_ChIP03_Erlotinib_pY1
- GSM6132741 ChIPseq_2281751_ChIP03_Erlotinib_EGF_pY1
+ 24 more — browse all 64 samples with per-sample file links →
- GSE284519 TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination [ChIP-seq] 93 samples shares receptor, chip-seq
- GSE222196 Treatment of prostate cancer cell lines with Androgen Receptor and Receptor Tyrosine Kinase inhibitors 246 samples shares receptor, tyrosine
- GSE280208 A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [ChIP-Seq] 33 samples shares polymerase, chip-seq
- GSE277183 RNA Polymerase II coordinates histone deacetylation at active promoters 158 samples shares polymerase
- GSE265883 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (CUT&RUN) 68 samples shares polymerase
- GSE302795 Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria-nucleus crosstalk 54 samples shares phosphorylate
- GSE293152 Hypoxia-responsive interaction between Cyclin T1, BHLHE40, and Tim8-Tim13 regulates RNA Polymerase II 43 samples shares polymerase
- GSE287902 BPTF regulstes androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction [Cut&Run] 40 samples shares receptor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.