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RNA-seq analysis JARID2 knockdown effect on MDA-MB-231 cells

GSE202868 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/05/11 Platform GPL16791
Summary
The JmjC domain-containing protein JARID2 is an important regulator of gene expression in embryonic stem cells. However, what role JARID2 play in tumorigenesis is poorly understood. Here, we reported that JARID2 was highly expressed in multiple types of cancer, including breast cancer. And JARID2 promoted the glycolysis, lipid metabolism, stemness, proliferation, and invasion of breast cancer cells. Furthermore, we found that JARID2 was physically interacted with the nucleosome remodeling and deacetylase (NuRD) complex transcriptionally repressing a series of tumor suppressor genes. Overall, our data propose that JARID2 promotes tumorigenesis and development, endorsing the proposal of JARID2 as a target for cancer therapy.
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Direct links to NCBI, no account and no request form: the whole study as GSE202868_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA837562 and SRA study SRP374938. Searching any of these in the dataset finder brings you back here.

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