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Fragile X Syndrome Patient-Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes

GSE202894 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/16 Platform GPL16791
Summary
Fragile X syndrome (FXS) is the most commonly inherited form of developmental and intellectual disability. Here, we used a new approach, i.e. neurons derived from FXS patients and transplanted in the mouse brain, to study this disease. It provided new insights into the development of FXS neurons, by facilitating their development in a 3D context: we found that FXS neurons had an altered maturation process, and our data suggest that their synapses might be hyperactive.
Published in
Fragile X Syndrome Patient-Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes
Krzisch MA, Wu H, Yuan B et al. · Biological psychiatry 2023 · PMID 36372569 · doi:10.1016/j.biopsych.2022.08.020
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Also filed as BioProject PRJNA837605 and SRA study SRP374966. Searching any of these in the dataset finder brings you back here.

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