COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 44 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- MelanomaThis series is part of our curated briefing on it.
- Samples
- 44 samples: 12 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- COP1 Deficiency in BRAF(V600E) Melanomas Confers Resistance to Inhibitors of the MAPK PathwayCells · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE203470_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA840909 and SRA study SRP376294. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 12 replicated groups read from 44 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6172698 WT [SAM24359722]
- GSM6172699 WT [SAM24359723]
- GSM6172700 WT [SAM24359724]
- GSM6172701 ETV1 KO [SAM24359725]
- GSM6172702 ETV1 KO [SAM24359726]
- GSM6172703 ETV1 KO [SAM24359727]
- GSM6172704 ETV5 KO [SAM24359728]
- GSM6172705 ETV5 KO [SAM24359729]
- GSM6172706 ETV5 KO [SAM24359730]
- GSM6172707 ETV1ETV4ETV5 KO [SAM24359731]
- GSM6172708 ETV1ETV4ETV5 KO [SAM24359732]
- GSM6172709 ETV1ETV4ETV5 KO [SAM24359733]
- GSM6172710 WT [SAM24335532]
- GSM6172711 WT [SAM24335533]
- GSM6172712 WT [SAM24335534]
- GSM6172713 COP1SNP [SAM24384938]
- GSM6172714 COP1SNP [SAM24384939]
- GSM6172715 COP1SNP [SAM24384940]
- GSM6172716 ETV5_ChIP_COP1SNP_rep1 ETV5_ChIP_COP1SNP
- GSM6172717 ETV5_ChIP_COP1SNP_rep2 ETV5_ChIP_COP1SNP
- GSM6172718 H3K27ac_ChIP_COP1SNP_1 H3K27ac_ChIP_COP1SNP
- GSM6172719 H3K27ac_ChIP_COP1SNP_2 H3K27ac_ChIP_COP1SNP
- GSM6172720 H3K4me3_ChIP_COP1SNP_1 H3K4me3_ChIP_COP1SNP
- GSM6172721 H3K4me3_ChIP_COP1SNP_2 H3K4me3_ChIP_COP1SNP
- GSM6172722 ETV5_ChIP_COP1WT_rep1 ETV5_ChIP_COP1WT
- GSM6172723 ETV5_ChIP_COP1WT_rep2 ETV5_ChIP_COP1WT
- GSM6172724 H3K27ac_ChIP_COP1WT_1 H3K27ac_ChIP_COP1WT
- GSM6172725 H3K27ac_ChIP_COP1WT_2 H3K27ac_ChIP_COP1WT
- GSM6172726 H3K4me3_ChIP_COP1WT_1 H3K4me3_ChIP_COP1WT
- GSM6172727 H3K4me3_ChIP_COP1WT_2 H3K4me3_ChIP_COP1WT
- GSM6172728 ETV5_ChIP_COP1SNP+ERKi_rep1 ETV5_ChIP_COP1SNP+ERKi
- GSM6172729 ETV5_ChIP_COP1SNP+ERKi_rep2 ETV5_ChIP_COP1SNP+ERKi
- GSM6172730 H3K27ac_ChIP_COP1SNP+ERKi_1 H3K27ac_ChIP_COP1SNP+ER…
- GSM6172731 H3K27ac_ChIP_COP1SNP+ERKi_2 H3K27ac_ChIP_COP1SNP+ER…
- GSM6172732 H3K4me3_ChIP_COP1SNP+ERKi_1 H3K4me3_ChIP_COP1SNP+ER…
- GSM6172733 H3K4me3_ChIP_COP1SNP+ERKi_2 H3K4me3_ChIP_COP1SNP+ER…
- GSM6172734 ETV5_ChIP_COP1WT+ERKi_rep1 ETV5_ChIP_COP1WT+ERKi
- GSM6172735 ETV5_ChIP_COP1WT+ERKi_rep2 ETV5_ChIP_COP1WT+ERKi
- GSM6172736 H3K27ac_ChIP_COP1WT+ERKi_1 H3K27ac_ChIP_COP1WT+ERKi
- GSM6172737 H3K27ac_ChIP_COP1WT+ERKi_2 H3K27ac_ChIP_COP1WT+ERKi
+ 4 more — browse all 44 samples with per-sample file links →
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.