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Treatment of LNCaP cells with novel PRMT5:MEP50 protein:protein interaction inhibitors

GSE206460 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/17 Platform GPL24676
Summary
We developed a novel compound for inhibition of PRMT5:MEP50 protein:protein interaction. LNCaP prostate cancer cells were treated with Compound 17 for 72 hours. Cells were harvested, RNA isolated, and then submitted for RNA-sequencing,
Published in
Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors
Asberry AM, Cai X, Deng X et al. · Journal of medicinal chemistry 2022 · PMID 36206451 · doi:10.1021/acs.jmedchem.2c01000
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Also filed as BioProject PRJNA851032 and SRA study SRP382696. Searching any of these in the dataset finder brings you back here.

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