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XBP1-mediated activation of STING signaling in macrophages contributes to the progression of liver fibrosis

GSE206693 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/17 Platform GPL24247
Summary
Our findings demonstrate that XBP1 controls macrophage cGAS/STING/NLRP3 activation by regulating macrophage self-mtDNA cytosolic leakage via BNIP3-mediated mitophagy modulation, providing a novel target against liver fibrosis.
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Also filed as BioProject PRJNA851778 and SRA study SRP383119. Searching any of these in the dataset finder brings you back here.

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