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Immune Profiling-Based Treatment for ANCA-Associated Glomerulonephritis with Ustekinumab

GSE207438 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/01 Platform GPL24676
Summary
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is a life-threatening systemic autoimmune disease that frequently presents as crescentic glomerulonephritis (GN) leading to kidney failure1. Despite recent advances2, treatment for most patients with ANCA-associated GN relies on unspecific immunosuppressive agents that are hazardous and only partially efficacious. To develop an anti-T-cell cytokine treatment strategy based on the immunopathogenesis of the individual patient, we established the combination of rapid single-cell immune profiling with standard histopathological analyses of renal biopsies. We report two patients with biopsy-proven ANCA-associated GN who presented with renal failure and active urinary sediment despite immunosuppressive therapy. Our data suggest that the integration of single-cell immune profiling with clinical and histopathological information facilitates personalized anti-cytokine therapies, such as ustekinumab in ANCA-GN, and warrants further investigation.
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Also filed as BioProject PRJNA855491 and SRA study SRP384809. Searching any of these in the dataset finder brings you back here.

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