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Chromatin reorganization drives expression of functional maturation genes in senescent pancreatic beta cells (Series2 - chromatin sccessibility, ATAC-seq)

GSE207818 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/06/26 Platform GPL18573
Summary
Using a unique model of cultured human beta cell senescence we show that chromatin reorganization leads to activation of enhancers regulating functional maturation genes, concomitantly with acquisition of glucose-stimulated insulin secretion capacity. Interferon-response genes are elevated in senescent beta cells, but cytokine-encoding senescence-associated secretory phenotype (SASP) genes are not. Human beta cell senescence thus involves chromatin-driven upregulation of a functional maturation program and of interferon-stimulated genes, changes that could increase both insulin secretion and immune reactivity.
Published in
Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
Patra M, Klochendler A, Condiotti R et al. · Nucleic acids research 2024 · PMID 38682582 · doi:10.1093/nar/gkae313
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Also filed as BioProject PRJNA857284 and SRA study SRP385691. Searching any of these in the dataset finder brings you back here.

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