Glioblastoma and its treatment are associated with extensive accelerated brain aging
RNA-seq (gene expression) · human · 35 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- GlioblastomaThis series is part of our curated briefing on it.
- Samples
- 35 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Glioblastoma and its treatment are associated with extensive accelerated brain agingAging cell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE207821_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA857283 and SRA study SRP385693. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 35 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6319731 Control_1_Near1 Control_1_Nea
- GSM6319732 Control_2_Near1 Control_2_Nea
- GSM6319733 Control_3_Near1 Control_3_Nea
- GSM6319734 Control_4_Near1 Control_4_Nea
- GSM6319735 Control_5_Near1 Control_5_Nea
- GSM6319736 NA_GBM_1_Near1 NA_GBM_1_Nea
- GSM6319737 NA_GBM_2_Near1 NA_GBM_2_Nea
- GSM6319738 NA_GBM_3_Near1 NA_GBM_3_Nea
- GSM6319739 NA_GBM_4_Near1 NA_GBM_4_Nea
- GSM6319740 NA_GBM_5_Near1 NA_GBM_5_Nea
- GSM6319741 AD_1_Near1
- GSM6319742 AD_2_Near1
- GSM6319743 AD_3_Near1
- GSM6319744 AD_4_Near1
- GSM6319745 AD_5_Near1
- GSM7946994 Control_1_Near2 Control_1_Nea
- GSM7946995 Control_2_Near2 Control_2_Nea
- GSM7946996 Control_3_Near2 Control_3_Nea
- GSM7946997 Control_4_Near2 Control_4_Nea
- GSM7946998 Control_5_Near2 Control_5_Nea
- GSM7946999 Control_1_Far
- GSM7947000 Control_2_Far
- GSM7947001 Control_3_Far
- GSM7947002 Control_4_Far
- GSM7947003 Control_5_Far
- GSM7947004 NA_GBM_1_Near2 NA_GBM_1_Nea
- GSM7947005 NA_GBM_2_Near2 NA_GBM_2_Nea
- GSM7947006 NA_GBM_3_Near2 NA_GBM_3_Nea
- GSM7947007 NA_GBM_4_Near2 NA_GBM_4_Nea
- GSM7947008 NA_GBM_5_Near2 NA_GBM_5_Nea
- GSM7947009 NA_GBM_1_Far
- GSM7947010 NA_GBM_2_Far
- GSM7947011 NA_GBM_3_Far
- GSM7947012 NA_GBM_4_Far
- GSM7947013 NA_GBM_5_Far
- GSE112648 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 18 samples same disease briefing · shares glioblastoma
- GSE131928 single cell RNA-seq analysis of adult and paediatric IDH-wildtype Glioblastomas 2 samples same disease briefing · shares glioblastoma
- GSE107560 Ivy Glioblastoma Atlas Project 305 samples same disease briefing · shares glioblastoma
- GSE13041 Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age 267 samples same disease briefing · shares glioblastoma
- GSE10878 Integrative Genome-wide Analysis of Glioblastoma. 60 samples same disease briefing · shares glioblastoma
- GSE112650 SOX4/11 Enhances NGN2 Reprogramming Glioblastoma Cells into Neuron Cells by Modulating RhoA and CDC42/RAC1 Pathway Activity 30 samples same disease briefing · shares glioblastoma
- GSE112645 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 12 samples same disease briefing · shares glioblastoma
- GSE115459 Exosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation 9 samples same disease briefing · shares glioblastoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.