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The role of MLF1 on accessible chromatin in AC16 cell line

GSE207907 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/01/29 Platform GPL24676
Summary
Previous studies found that MLF1 mRNA levels tended to decline in aging hearts. Functional studies found that knockdown of MLF1 ameliorated the drug-induced cellular senescence phenotype. Here, we apply transcriptomics to explore the underlying molecular mechanisms.
Published in
Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening
Lv J, Chen Q, Wang J et al. · Nucleic acids research 2025 · PMID 39657728 · doi:10.1093/nar/gkae1176
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Also filed as BioProject PRJNA857661 and SRA study SRP385871. Searching any of these in the dataset finder brings you back here.

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