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Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation

GSE208436 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/11 Platform GPL21103
Summary
We report that Nup358, a nucleoporin linked to acute myeloid leukemia and myeloproliferative neoplasms, is required for the developmental progression of early myeloid progenitors. We found that loss of Nup358 in mice is associated with the accumulation of myeloid-primed multipotent progenitors (MPPs) in bone marrow and the loss of myeloid-committed progenitors and mature myeloid cells. Accumulated MPPs in Nup358 knockout mice are greatly restricted to megakaryocyte/erythrocyte biased MPP2 cells and fail to progress into committed myeloid progenitors.
Published in
Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation
Guglielmi V, Lam D, D'Angelo MA · Science advances 2024 · PMID 38838144 · doi:10.1126/sciadv.adn8963
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Also filed as BioProject PRJNA859912 and SRA study SRP386974. Searching any of these in the dataset finder brings you back here.

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