GEO series
Transcriptomic profiling of blood mTreg and mTeff from healthy control (HC) and multiple sclerosis (MS) [RNA-Seq]
GSE209596
Homo sapiens
Expression profiling by high throughput sequencing
77 samples
2024/09/30
GPL16791
Summary
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. While CD4+Foxp3+ regulatory T cells (Tregs) play a central role in preventing autoimmunity, the molecular mechanism underlying their dysfunction is unknown. Here, we performed comprehensive transcriptional and epigenetic profiling of Tregs in multiple sclerosis (MS) to identify central transcriptional programs regulating human autoimmunity.
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Paper (PMID 39196959) ↗
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