Inhibiting EZH2 Targets Atypical Teratoid Rhabdoid Tumor by Triggering Viral Mimicry via Both RNA and DNA Sensing Pathways [RNA-Seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × UNC1999,Day4, vs 3 × UNC1999,Day6, vs 3 × UNC2400,Day4, vs 3 × UNC2400,Day6,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathwaysNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE213249_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA880266 and SRA study SRP396906. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6576523 UNC1999,Day4,Rep1 UNC1999,Day4,
- GSM6576524 UNC1999,Day4,Rep2 UNC1999,Day4,
- GSM6576525 UNC1999,Day4,Rep3 UNC1999,Day4,
- GSM6576526 UNC1999,Day6,Rep1 UNC1999,Day6,
- GSM6576527 UNC1999,Day6,Rep2 UNC1999,Day6,
- GSM6576528 UNC1999,Day6,Rep3 UNC1999,Day6,
- GSM6576529 UNC2400,Day4,Rep1 UNC2400,Day4,
- GSM6576530 UNC2400,Day4,Rep2 UNC2400,Day4,
- GSM6576531 UNC2400,Day4,Rep3 UNC2400,Day4,
- GSM6576532 UNC2400,Day6,Rep1 UNC2400,Day6,
- GSM6576533 UNC2400,Day6,Rep2 UNC2400,Day6,
- GSM6576534 UNC2400,Day6,Rep3 UNC2400,Day6,
- GSE213248 Inhibiting EZH2 Targets Atypical Teratoid Rhabdoid Tumor by Triggering Viral Mimicry via Both RNA and DNA Sensing Pathways [CUT&RUN] 24 samples shares ezh2, inhibiting, triggering, atypical, teratoid, rhabdoid, targets, mimicry
- GSE230742 Investigation of genetic dependencies in atypical teratoid rhabdoid tumors (ATRTs) [I] 21 samples shares atypical, teratoid, rhabdoid
- GSE276501 Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy 18 samples shares atypical, teratoid, rhabdoid
- GSE283833 A cycling, progenitor-like cell population at the root of atypical teratoid rhabdoid tumor subtype differentiation trajectories [bulk RNA-Seq] 16 samples shares atypical, teratoid, rhabdoid
- GSE282972 An in vitro pharmacogenomic approach reveals subtype-specific therapeutic vulnerabilities in atypical teratoid/rhabdoid tumors (AT/RT) [RNASeq] 13 samples shares atypical, teratoid, rhabdoid
- GSE283839 A cycling, progenitor-like cell population at the root of atypical teratoid rhabdoid tumor subtype differentiation trajectories [snRNA_10Xv3] 12 samples shares atypical, teratoid, rhabdoid
- GSE231286 Investigation of genetic dependencies in atypical teratoid rhabdoid tumors (ATRTs) [II] 12 samples shares atypical, teratoid, rhabdoid
- GSE283843 A cycling, progenitor-like cell population at the root of atypical teratoid rhabdoid tumor subtype differentiation trajectories 56 samples shares atypical, teratoid, rhabdoid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.