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Super-enhancer-driven PPP1R15B/CReP, regulated by C/EBPβ and YY1, is oncogenic in multiple myeloma

GSE213556 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/06/25 Platform GPL24676
Summary
We identified a novel super-enhance-driven oncogene PPP1R15B overexpressed in multiple myeloma as compared to normal plasma cells and B lymphoma cells. We used PPP1R15B specific shRNAs to study its function.
Published in
Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma
Xiong S, Zhou J, Tan TK et al. · Nature communications 2024 · PMID 39122682 · doi:10.1038/s41467-024-50910-z
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Also filed as BioProject PRJNA881324 and SRA study SRP397685. Searching any of these in the dataset finder brings you back here.

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