Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Bladder cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × 786-O cells, sh control vs 3 × 786-O cells, shCBX7 vs 3 × 5637 cells, shCBX7Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE214886_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA887467 and SRA study SRP401209. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6617440 786-O cells, sh control_1 786-O cells, sh control
- GSM6617441 786-O cells, sh control_2 786-O cells, sh control
- GSM6617442 786-O cells, sh control_3 786-O cells, sh control
- GSM6617443 786-O cells, shCBX7_1 786-O cells, shCBX7
- GSM6617444 786-O cells, shCBX7_2 786-O cells, shCBX7
- GSM6617445 786-O cells, shCBX7_3 786-O cells, shCBX7
- GSM6617446 5637 cells, sh control_1
- GSM6617447 5638 cells, sh control_1
- GSM6617448 5639 cells, sh control_1
- GSM6617449 5637 cells, shCBX7_1 5637 cells, shCBX7
- GSM6617450 5637 cells, shCBX7_2 5637 cells, shCBX7
- GSM6617451 5637 cells, shCBX7_3 5637 cells, shCBX7
- GSE176493 Comprehensive target engagement by EZH2 inhibitor CPI-0209 allows for preferential targeting of ARID1A mutant urothelial carcinoma 252 samples same disease briefing · shares ezh2
- GSE217413 Cisplatin resistance driver gene CLSPN product is a target for immunotherapy in urothelial carcinoma. 4 samples same disease briefing · shares cisplatin
- GSE181389 Transcriptome profiling of HOXA13 and HOXB13 expression knockdown in bladder cancer cell lines. 59 samples same disease briefing
- GSE193755 Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 12 samples same disease briefing
- GSE211924 UCHL5 promotes Tumorigenesis of Bladder Cancer by Activating AKT/mTOR signaling pathway and targeting c-myc, SLC25A19, and ICAM5. 9 samples same disease briefing
- GSE172359 Combination of urine exosomal mRNAs and lncRNAs as novel diagnostic biomarkers for bladder cancer 6 samples same disease briefing
- GSE182310 Transcriptome sequence of Human bladder cancer cell line 6 samples same disease briefing
- GSE193753 Human bladder cancer cell line high throughput sequencing - genes regulated by hMSH2 - CDDP therapy 6 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.