FAD4T mouse model reflects Alzheimer’s disease pathobiology in bone marrow-brain axis
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD(4T) mouse modelJournal of orthopaedic translation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE214917_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA887736 and SRA study SRP401327. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6617906 FAD4T-B-F-2M
- GSM6617907 FAD4T-B-M-2M
- GSM6617908 FAD4T-BM-F-2M
- GSM6617909 FAD4T-BM-M-2M
- GSM6617910 FAD4T-B-F-8M
- GSM6617911 FAD4T-B-M-8M
- GSM6617912 FAD4T-BM-F-8M
- GSM6617913 FAD4T-BM-M-8M
- GSM6617914 WT-B-F-2M
- GSM6617915 WT-B-M-2M
- GSM6617916 WT-BM-F-2M
- GSM6617917 WT-BM-M-2M
- GSM6617918 WT-B-F-8M
- GSM6617919 WT-B-M-8M
- GSM6617920 WT-BM-F-8M
- GSM6617921 WT-BM-M-8M
- GSE319246 ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer’s Disease via Epigenetic Reprogramming of the AsxL1/LXRα–H3K4me3 Axis 24 samples shares alzheimer, axis
- GSE329430 Bone marrow myelopoiesis dysfunction in Alzheimer’s disease 20 samples shares alzheimer, bone
- GSE176506 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease 112 samples shares alzheimer
- GSE98969 Single cell RNA-seq identifies a unique microglia type associated with Alzheimer’s disease [RNA] 97 samples shares alzheimer
- GSE254970 Age, Sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients 77 samples shares alzheimer
- GSE176505 Synergistic behavioral and neuroinflammatory effects of amyloid neuropathology and sepsis survival in a murine model of Alzheimer’s disease II 72 samples shares alzheimer
- GSE246244 Designed macrocyclic peptide rescues behavioral impairment and brain pathology in an Alzheimer’s disease mouse model 71 samples shares alzheimer
- GSE304212 Molecular Pathogenesis of Alzheimer's Disease Onset in a Mouse Model: Effects of Cannabidiol Treatment 60 samples shares alzheimer
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.