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A HDAC4-HDAC2 complex composes an epigenetic sensor that links the DNA damage response to the senescent program by erasing H2BK120 acetylation [II]

GSE216861 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/06/18 Platform GPL21697
Summary
Purpose: Identification of SEs in time course after HDAC4 depletion and correlation to the accumulation of DNA damage. Outcome: We discovered a novel epigenetic complex formed by HDAC4 and HDAC2 that is involved in the erasure of H2BK120 acetylation. The HDAC4/HDAC2 complex, through the dynamic deacetylation of H2BK120, modulates the efficiency of DNA repair by homologous recombination (HR) by controlling the recruitment of BRCA1 and CtIP to the site of lesions. Degradation of HDAC4 during senescence has a dual effect. First, it contributes to super-enhancers activation by limiting HDAC3 activity, and second, it causes the accumulation of damaged DNA.
Published in
HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair
Di Giorgio E, Dalla E, Tolotto V et al. · Nucleic acids research 2024 · PMID 38874468 · doi:10.1093/nar/gkae501
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Also filed as BioProject PRJNA895720. Searching any of these in the dataset finder brings you back here.

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