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Human arterial endothelial cells from pluripotent stem cells for in vitro hematopoiesis and lymphopoiesis

GSE217705 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/01 Platform GPL24676
Summary
Arterial endothelial cells (AECs) are the founder cell for intraembryonic haematopoiesis. Here, we report a method for the efficient generation of human haemogenic DLL4+ AECs from pluripotent stem cells (PSC). Time-series single cell RNA-sequencing revealed the dynamic evolution of haematopoiesis and lymphopoiesis from endothelial stage, generating cell types with counterparts present in early human embryos. Our study describes an efficient method for producing lymphoid cells and provides insights into their endothelial and haematopoietic ontogeny, paving a new path to investigations of the human blood system.
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Also filed as BioProject PRJNA900196 and SRA study SRP407191. Searching any of these in the dataset finder brings you back here.

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