Fosl2 overexpression and Ezh2 inhibition in mouse embryonic fibroblasts
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin openingCell metabolism · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE217780_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA900535 and SRA study SRP407470. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6726655 A10_LNeg_1_S7
- GSM6726656 A11_LNeg_2_S8
- GSM6726657 A12_LNeg_3_S9
- GSM6726658 A13_LFosL2_1_S10
- GSM6726659 A14_LFosL2_2_S11
- GSM6726660 A15_LFosL2_3_S12
- GSM6726661 A1_ENeg_1_S1
- GSM6726662 A2_ENeg_2_S2
- GSM6726663 A7_EFosL2_1_S4
- GSM6726664 A8_EFosL2_2_S5
- GSM6726665 A9_EFosL2_3_S6
- GSM8321979 A3_ENeg_3_S3
- GSM8321980 A4_Ezh2I_1_S27
- GSM8321981 A5_Ezh2I_2_S28
- GSM8321982 A6_Ezh2I_3_S29
- GSE304090 Pharmacological inhibition of the epigenetic enzyme EZH2 attenuates cardiac dysfunction and mitigates lipid metabolism perturbations in a murine model of myocardial infarction 15 samples shares ezh2, inhibition
- GSE232845 Effect of conditional triple-knockout of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c or overexpression of KDM4C/JMJD2C mutants with different phase separation ability on gene expression in mouse embryonic stem cells. [ChIP-Seq] 46 samples shares overexpression, embryonic
- GSE287243 KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan [CUT&TAG] 20 samples shares overexpression, embryonic
- GSE182731 Inhibition of ATM in Mouse-derived lung fibroblasts 27 samples shares fibroblasts, inhibition
- GSE21755 Rapamycin effect on Wild Type and TSC deficient Mouse Embryonic Fibroblasts : Time Course 25 samples shares fibroblasts, embryonic
- GSE319079 RNA-Seq analysis of p27+/+ and p27-/- mouse embryonic fibroblasts grown in full medium for 24 h 12 samples shares fibroblasts, embryonic
- GSE232844 Effect of conditional triple-knockout of Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c or overexpression of KDM4C/JMJD2C mutants with different phase separation ability on gene expression in mouse embryonic stem cells. [RNA-Seq] 10 samples shares overexpression, embryonic
- GSE306012 Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction 28 samples shares fibroblasts, inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.