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FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis

GSE220108 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/03/29 Platform GPL20795
Summary
The lymph nodes (LN) are the most frequent metastatic sites of esophageal squamous cell carcinoma (ESCC), but the associated mechanisms are poorly understood. Tumor cells lodge and survive at the metastatic site during the early adaptation step, which is the bottleneck for successful metastasis. However, the phenotypic and molecular characteristics of tumor cells that contribute to this key process remain elusive. Here, we established a robust human xenograft spontaneous LN metastasis model to capture individual cancer cells and used single-cell RNA sequencing to profile transcriptomic changes in cancer cells during different steps of metastasis.
Published in
FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis
Li SS, Zhang B, Huang C et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 40215279 · doi:10.1073/pnas.2411241122
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Also filed as BioProject PRJNA908812 and SRA study SRP411371. Searching any of these in the dataset finder brings you back here.

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