AAV-CYP46A1 gene therapy in mouse models of Huntington’s disease
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 6 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington's diseaseActa neuropathologica communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE220224_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA909255 and SRA study SRP411651. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 6 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6796918 R6/2 NI, 41 R6/2 NI,
- GSM6796919 R6/2 NI, 34 R6/2 NI,
- GSM6796920 R6/2 NI, 36 R6/2 NI,
- GSM6796921 R6/2 NI, 1 R6/2 NI,
- GSM6796922 R6/2 Stuffler, 31 R6/2 Stuffler,
- GSM6796923 R6/2 Stuffler, 16 R6/2 Stuffler,
- GSM6796924 R6/2 Stuffler, 42 R6/2 Stuffler,
- GSM6796925 R6/2 Stuffler, 7 R6/2 Stuffler,
- GSM6796926 WT Stuffler, 24 WT Stuffler,
- GSM6796927 WT Stuffler, 40 WT Stuffler,
- GSM6796928 WT Stuffler, 5 WT Stuffler,
- GSM6796929 WT Stuffler, 15 WT Stuffler,
- GSM6796930 R6/2 CAG, 12 R6/2 CAG,
- GSM6796931 R6/2 CAG, 33 R6/2 CAG,
- GSM6796932 R6/2 CAG, 20 R6/2 CAG,
- GSM6796933 R6/2 CAG, 18 R6/2 CAG,
- GSM6796934 R6/2 CAG, 23 R6/2 CAG,
- GSM6796935 R6/2 hSYN, 26 R6/2 hSYN,
- GSM6796936 R6/2 hSYN, 17 R6/2 hSYN,
- GSM6796937 R6/2 hSYN, 27 R6/2 hSYN,
- GSM6796938 R6/2 hSYN, 43 R6/2 hSYN,
- GSM6796939 R6/2 hSYN, 39 R6/2 hSYN,
- GSM6796940 R6/2 GFA2, 21 R6/2 GFA2,
- GSM6796941 R6/2 GFA2, 3 R6/2 GFA2,
- GSM6796942 R6/2 GFA2, 10 R6/2 GFA2,
- GSM6796943 R6/2 GFA2, 35 R6/2 GFA2,
- GSM6796944 R6/2 GFA2, 37 R6/2 GFA2,
- GSE284504 Transcriptional profiling of brain from a zQ175 KI mouse model of Huntington's disease 335 samples shares huntington
- GSE281823 Transcriptional profiling of striatum from the Q140 mouse model of Huntington's disease, from A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy 40 samples shares huntington
- GSE270727 Analysis of striatal zinc finger protein (ZFP) repression of mutant Huntingtin (HTT) in the zQ175DN knock-in mouse model of Huntington's disease (bulk RNA-seq) 233 samples shares huntington
- GSE284500 Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a 192 samples shares huntington
- GSE284497 Transcriptional profiling of striatum from a zQ175 KI mouse model of Huntington's disease treated with HTT-10150 siRNA targeting full-length Htt 143 samples shares huntington
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares huntington
- GSE270728 Analysis of striatal zinc finger protein (ZFP) repression of mutant Huntingtin (HTT) in the zQ175DN knock-in mouse model of Huntington's disease (snRNA-seq) 120 samples shares huntington
- GSE288739 Transcriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Pms1 heterozygous and homozygous mice 96 samples shares huntington
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.