GEO series
Role of MYC acetylated lysine residues in cell transformation and gene-selective regulation [MCF10A]
GSE220918
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2024/03/20
GPL24676
Summary
The functions of MYC acetylation have remained unclear. In this study we identified the major lysine residues of MYC that are acetylated by p300 and GCN5 in cancer cell lines and established the requirment of three specific acetyl-lysine (AcK) residues for MYC transformation of Rat1a fibroblasts and MCF10 mammary epithelial cells. We further uncovered gene-selective regulatory functions and conserved genetic programs and biolofical processes regulated by MYC AcK residues in both cell types.
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Paper (PMID 37852796) ↗
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