GEO series
CRISPRai Perturb-seq [Series 1]
GSE220974
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2024/03/14
GPL24676
Summary
We develop a system for bidirectional epigenetic editing (CRISPRai), in which orthogonal activating (CRISPRa) and repressive (CRISPRi) perturbations are applied simultaneously to multiple loci the same cell. We perform Perturb-seq, a method for single-cell RNA-seq paired with CRISPR guide RNA (gRNA) detection, on cells perturbed using CRISPRai for a panel of pairwise combinations of genes in K562 cells.
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Paper (PMID 38760566) ↗
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