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Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia

GSE221459 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/15 Platform GPL24676
Summary
We identified novel nicotinamide-based FLT3 inhibitors ( HSN748) that specifically target FLT3-ITD at sub-nanomolar concentrations and are effective against drug-resistant secondary mutations. In the current study, we evaluated these compounds’ antileukemic activity against FLT3-ITD and gatekeeper mutations in drug-resistant AML, relapsed/refractory AMLs with FLT3 mutations
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Direct links to NCBI, no account and no request form: the whole study as GSE221459_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA914332 and SRA study SRP414166. Searching any of these in the dataset finder brings you back here.

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