← BioTransfer GEO Dataset Finder
GEO series

Genome-Wide Binding Analysis of LIRIL2R in Induced Regulatory T Cells

GSE221757 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/05/15 Platform GPL24676
Summary
Factors that determine the epigenetic landscape of regulatory T cells (Tregs), which is critical for their function, remain poorly understood. Long intergenic noncoding RNAs (LincRNA)s are important for shaping and maintaining the epigenetic landscape in different cell types. We identified a novel uncharacterised lincRNA, which we named LincRNA regulator of IL2RA (LIRIL2R), that is upregulated during early differentiation of human Tregs. RNA sequencing (RNA-seq) and data independent (DIA) proteomic analysis of LIRIL2R-deficient Tregs, with genome-wide chromatin occupancy analysis, identified IL2RA as direct LIRIL2R target. This nuclear lincRNA directly binds upstream of IL2RA locus and regulates its transcription by facilitating the accessibility of the locus. LIRIL2R-deficient Tregs had reduced expression of Treg-related genes, including FOXP3, IL2RA, STAT5, CTLA4 and PDCD1, as well as reduced suppressive capacity. Modulating LIRIL2R expression may hold promise for better therapeutic strategies against autoimmunity and cancer.
Published in
Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4(+) regulatory T cells by regulating IL2RA
Andrabi SBA, Kalim UU, Palani S et al. · Proceedings of the National Academy of Sciences of the United States of America 2024 · PMID 38805281 · doi:10.1073/pnas.2315363121
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE221757_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA915968 and SRA study SRP414842. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.