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Effect of Irg1-Itaconate on Nrf2-transcripting genes in macrophages by using chromatin immunoprecipitation-sequencing (ChIP-seq) assays.

GSE221843 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/06/28 Platform GPL24247
Summary
To investigate the role of Irg1-itacaonate on Nrf2-transcripting genes in macrophages, RAW264.7 cells were cultured and were treated 120 μM 4-octyl itaconate (4-OI) or Vehicle for 8 h. We then performed ChIP-seq analysis from 4-OI or vehicle treated RAW264.7 cells using Nrf2 or IgG antibodies.
Published in
Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis
Luo Z, Sheng Z, Hu L et al. · EBioMedicine 2024 · PMID 38324982 · doi:10.1016/j.ebiom.2024.104993
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Also filed as BioProject PRJNA916479 and SRA study SRP415035. Searching any of these in the dataset finder brings you back here.

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