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Single-Cell ATAC+RNAseq from CD34+ cells of a Primary Myelofibrosis patient evolved to secondary Acute Myeloid Leukemia

GSE221946 Homo sapiens Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/04/29 Platform GPL21697
Summary
To characterize the impact of chromatin remodelers’ mutations in MPN onset and development and identify regulatory elements driving gene expression modulations during disease progression, we performed a single-nucleus RNAseq coupled with single-cell ATACseq experiment on CD34+ cells from the chronic and blast phase of a Primary Myelofibrosis patient.
Published in
Clonal dynamics and copy number variants by single-cell analysis in leukemic evolution of myeloproliferative neoplasms
Calabresi L, Carretta C, Romagnoli S et al. · American journal of hematology 2023 · PMID 37399248 · doi:10.1002/ajh.27013
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Also filed as BioProject PRJNA916925 and SRA study SRP415285. Searching any of these in the dataset finder brings you back here.

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