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TCF4 is a key mediator of cell identity in neuroblastoma and vulnerable to protein degradation by multiple epigenetic factors [ChIP-seq]

GSE222213 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/08/05 Platform GPL24676
Summary
Neuroblastomas (NBs) are aggressive pediatric tumors that are responsible for up to 15% of all pediatric cancer deaths. Two differentiation states exist in NB tumors, a majority of more committed ADRN tumor cells and a minority of neural crest cell (MES/NCC)-like cells. The transition between identity states is governed by different sets of master TFs that collectively form core regulatory circuitries (CRC) that drive high expression of downstream lineage-specific genes. In this study we aim to discover new lineage dependency factors in NB. Here, we identified the E-box transcription factor TCF4 (E2-2) not previously reported in NB to be a critical factor shared across both NB states and play important role in driving NB oncogenesis. We performed multiple functional and high-throughput analysis to delineate the unrecognized function of TCF4 in NB 
Published in
Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting MYC activity
Aljouda NA, Shrestha D, DeVaux C et al. · Molecular oncology 2025 · PMID 39119816 · doi:10.1002/1878-0261.13714
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Direct links to NCBI, no account and no request form: the whole study as GSE222213_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA918614. Searching any of these in the dataset finder brings you back here.

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