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Regeneration signatures of TGFB1-treated mouse intestinal organoids and Ki67 positive primary cells sorted from mice after irradiation

GSE222505 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 43 samples Submitted 2023/02/08 Platform GPL30215Platform GPL30172Platform GPL24247
Summary
The adult gut epithelium has a remarkable ability to recover from damage, a process that involves a temporary transition to a fetal-like state during regeneration. To achieve the goal of cellular therapies to restore and/or replace defective gastrointestinal epithelia, it is important to discover the natural components of the regenerative process. We employed a combination of –omics approaches, mouse genetic models, and murine and human organoids to characterize a role for TGFB in recovery from irradiation. In organoid culture conditions, TGFB1-treatment was necessary and sufficient to induce a transcriptomic shift to the fetal-like/regenerative state.
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Also filed as BioProject PRJNA922228 and SRA study SRP416732. Searching any of these in the dataset finder brings you back here.

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