Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors
RNA-seq (gene expression) · human · 148 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Ovarian cancerThis series is part of our curated briefing on it.
- Samples
- 148 samples: 37 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neoadjuvant PARPi or chemotherapy in ovarian cancer informs targeting effector Treg cells for homologous-recombination-deficient tumorsCell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222557_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA922522. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 82 samples.
How we read this: 37 replicated groups read from 148 sample titles; they account for 82 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6925939 01049 01049
- GSM6925940 01050 01050
- GSM6925941 01051 01051
- GSM6925942 01052 01052
- GSM6925943 01053 01053
- GSM6925944 01054 01054
- GSM6925945 01055 01055
- GSM6925946 01056 01056
- GSM6925947 01060 01060
- GSM6925948 02008 02008
- GSM6925949 scTCR-seq_01049 scTCR-seq
- GSM6925950 scTCR-seq_01050 scTCR-seq
- GSM6925951 scTCR-seq_01051 scTCR-seq
- GSM6925952 scTCR-seq_01052 scTCR-seq
- GSM6925953 scTCR-seq_01053 scTCR-seq
- GSM6925954 scTCR-seq_01054 scTCR-seq
- GSM6925955 scTCR-seq_01055 scTCR-seq
- GSM6925956 scTCR-seq_01056 scTCR-seq
- GSM6925957 scTCR-seq_01060 scTCR-seq
- GSM6925958 scTCR-seq_02008 scTCR-seq
- GSM6925959 P01_P1-1
- GSM6925960 P01_P2-1
- GSM6925961 P02_M1-1
- GSM6925962 P02_M2-1
- GSM6925963 P02_P2-1
- GSM6925964 P03_M1-1
- GSM6925965 P03_M2-1
- GSM6925966 P04_M1-1
- GSM6925967 P04_M2-1
- GSM6925968 P04_P1-1 P04_P1
- GSM6925969 P04_P1-2 P04_P1
- GSM6925970 P05_M1-1
- GSM6925971 P05_M2-1
- GSM6925972 P06_M1-1
- GSM6925973 P06_P1-1
- GSM6925974 P06_P2-1
- GSM6925975 P07_M1-1
- GSM6925976 P08_M1-1
- GSM6925977 P08_M2-1
- GSM6925978 P08_P1-1
+ 108 more — browse all 148 samples with per-sample file links →
- GSE268514 Integrative genomic analysis of Korean high-grade serous ovarian cancer 161 samples same disease briefing · shares ovarian
- GSE57477 Molecular subtyping of serous ovarian tumors reveals multiple connections to intrinsic breast cancer subtypes 72 samples same disease briefing · shares ovarian
- GSE314300 Rb CUT&RUN profiling in ovarian cancer cell lines following CDK2 inhibitor treatment 10 samples same disease briefing · shares ovarian
- GSE135242 Hi-C identifies structural variation associated with resistance in paired patient-derived ovarian cancer models 8 samples same disease briefing · shares ovarian
- GSE311212 Transcriptomic profiling in human ovarian cancer cell line OVCAR-3 following CDK2 inhibitor treatment 6 samples same disease briefing · shares ovarian
- GSE154600 Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma 5 samples same disease briefing · shares ovarian
- GSE128098 TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target 4 samples same disease briefing · shares ovarian
- GSE28330 Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents 107 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.