Cancer-cell-secreted miR-9-5p regulates cholesterol homeostasis to promote tumor metastasis [TF TB Rab27AKD miR-9KO]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Liver tumor free vs 3 × Liver tumor bearing vs 3 × Liver 231/Rab27A KD vs 3 × Liver 231/miR-9 KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in miceNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222707_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA923246 and SRA study SRP417163. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6929221 Liver tumor free_1 Liver tumor free
- GSM6929222 Liver tumor free_2 Liver tumor free
- GSM6929223 Liver tumor free_3 Liver tumor free
- GSM6929224 Liver tumor bearing_1 Liver tumor bearing
- GSM6929225 Liver tumor bearing_2 Liver tumor bearing
- GSM6929226 Liver tumor bearing_3 Liver tumor bearing
- GSM6929227 Liver 231/Rab27A KD_1 Liver 231/Rab27A KD
- GSM6929228 Liver 231/Rab27A KD_2 Liver 231/Rab27A KD
- GSM6929229 Liver 231/Rab27A KD_3 Liver 231/Rab27A KD
- GSM6929230 Liver 231/miR-9 KO_1 Liver 231/miR-9 KO
- GSM6929231 Liver 231/miR-9 KO_2 Liver 231/miR-9 KO
- GSM6929232 Liver 231/miR-9 KO_3 Liver 231/miR-9 KO
- GSE222622 Cancer-cell-secreted miR-9-5p regulates cholesterol homeostasis to promote tumor metastasis [PBS, MCF-10A EV and MDA-MB-231 EV] 9 samples shares mir-9-5p, cancer-cell-secreted, cholesterol, homeostasis, metastasis, promote
- GSE222623 Cancer-cell-secreted miR-9-5p regulates cholesterol homeostasis to promote tumor metastasis [vehicle and 25-HC] 6 samples shares mir-9-5p, cancer-cell-secreted, cholesterol, homeostasis, metastasis, promote
- GSE222708 Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice. 27 samples shares mir-9-5p, cholesterol, homeostasis, metastasis, promote
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.