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RNA-seq data of metformin treated MDA-MB-231 cells

GSE222767 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/03 Platform GPL24676
Summary
Our previous studies in Triple-Negative Breast Cancers (TNBCs) have demonstrated high fatty acid Beta-oxidation (FAO) and Electron Transport Chain (ETC) dependency to activate Src kinase by the Y419 autophosphorylation of Src. Higher doses of metformin have been shown to directly inhibit complex I of ETC. Here, analysis of RNA-seq data upon treatment with high concentration of metformin reveals inhibition of various oncopathways including the Src kinase pathway. Our study identifies a clinically relevant therapeutic approach to better manage poorly-targetable TNBCs.
Published in
Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway
Park JH, Jung KH, Jia D et al. · Cell reports. Medicine 2025 · PMID 39933530 · doi:10.1016/j.xcrm.2025.101941
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Direct links to NCBI, no account and no request form: the whole study as GSE222767_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA923339 and SRA study SRP417233. Searching any of these in the dataset finder brings you back here.

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