← BioTransfer GEO Dataset Finder
GEO series

Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma II

GSE223337 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/10 Platform GPL21290
Summary
Patient-derived primary GSCs were established from discarded specimens obtained from glioblastoma (GBM) patients undergoing surgery at UT Health San Antonio. We examined global transcriptional changes by RNA-sequencing using patient derived glioma stem cells (GSCs) treated with either vehicle, KDM1A inhibitor (NCD38) or temozolomide (TMZ) , or combination of NCD38+TMZ. Patient-derived GSCs (GSC082209) were treated with vehicle or NCD38 (3 µM) or TMZ (50 µM) or NCD38+TMZ for 24 hours. The RNA was isolated and utilized for RNA-seq analysis.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE223337_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA925833 and SRA study SRP418426. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.