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Transcriptomic evidence of lung repair in paediatric ARDS survival

GSE223793 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2024/06/22 Platform GPL24676
Summary
Pediatric patients survive from acute respiratory distress syndrome (ARDS) better than adults. However, immunological characteristics of lung tissue and peripheral circulation in pediatric ARDS has been scared. A 10-year-old girl suffered from ARDS was treated with anti-infection, anti-inflammatory regimen and with ECMO support. Air leak was fixed by surgery. Surgically dissected lung biopsies and peripheral blood cells (PBCs) were obtained from this patient and other control subjects for single cell RNA sequencing analysis. Pathological examination was also conducted on the lung biopsy. Out data revealed transcriptional characteristics of PBCs and lung microenvironment during ARDS recovery phase, and pointed out that efficient oxygen supply, appropriate immune regulation, and adequate anti-infection treatment favor for the recovery of children from ARDS.
Published in
Transcriptomic evidence of lung repair in paediatric ARDS survival
Song L, Li K, Hong X et al. · Clinical and translational medicine 2023 · PMID 37592372 · doi:10.1002/ctm2.1366
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Also filed as BioProject PRJNA928385 and SRA study SRP419292. Searching any of these in the dataset finder brings you back here.

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