GEO series
Early Transcriptional Responses to Human Paratyphoid Challenge
GSE224006
Homo sapiens
Expression profiling by high throughput sequencing
39 samples
2025/01/01
GPL20301
Summary
The whole blood transcriptome 12 hours after challenge with S. Paratyphi A. Samples were collected in a study aiming to find the challenge dose giving a 60-75% attack rate, published in Dobinson et al. PMID: 28158395. Participants were challenged with S. Paratyphi A NVGH308 strain suspended in sodium bicarbonate. Enteric fever was diagnosed based on oral temperature or positive blood culture. Participants were treated with antibiotics either following diagnosis or 14 days without diagnosis. Paired baseline samples are available under Series GSE114033.
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