GEO series
ST105-01: UNBIASED IN-VIVO AND IN-SILICO TL-532 MECANISM OF ACTION BY RNA-SEQUENCING
GSE224041
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/05/31
GPL19057
Summary
Tollys characterized and patented a family of TLR3 proprietary ligands, including the drug candidate TL-532 considered in this study. The aim of this project is to use unbiassed high-throughput transcriptomic approach to decipher signaling pathways linked to the mechanisms of action of the drug candidate TL-532 (including induction of programmed death, immunological activation, TH1 and BDCA3 response, cytokines and chemokines expression, angiogenesis, infiltrates, etc.), induced early (3h, 6h and 24h post-treatment), after a single locoregional treatment, at a dose known to be very effective in this model.
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