← BioTransfer GEO Dataset Finder
GEO series

Single cell analysis reveals immune subtypes associated with CRT treatment

GSE224327 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/16 Platform GPL24676
Summary
Cervical cancer (CC) is one of the most prevalent female malignancies globally in low- and middle-income regions, accounting for 7.5% of all female cancer deaths.Despite advancements in medical technology and treatment protocols,the combination of radiation therapy and chemotherapy, known as chemoradiotherapy (CRT), remains the standard of care for locally advanced cervical cancer. However, a substantial proportion of patients do not achieved a complete response to CRT, leading to treatment failure and poor clinical outcomes.Herein, we profiled the transcriptome of 50649 cells derived from six partial responsive(PR) tumor tissues and two complete responsive(CR) tissues of CSCC through scRNA-seq. We displayed a comprehensive cell landscape of the TME and investigated its function and lineage tracking.
Published in
Single-cell RNA sequencing analysis reveals a lack of CXCL13(+) T cell subsets associated with the recurrence of cervical squamous cell carcinoma following concurrent chemoradiotherapy
Li X, Cheng Y, Ji M et al. · Cancer immunology, immunotherapy : CII 2025 · PMID 40464813 · doi:10.1007/s00262-025-04083-3
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE224327_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA930652 and SRA study SRP420742. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.