RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Pancreatic cancerThis series is part of our curated briefing on it.
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signallingCellular signalling · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE224502_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA931328 and SRA study SRP420885. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7025196 PANC-1 cells, shControl, biological replicate 1 PANC-1 cells, shControl,
- GSM7025197 PANC-1 cells, shControl, biological replicate 2 PANC-1 cells, shControl,
- GSM7025198 PANC-1 cells, shControl, biological replicate 3 PANC-1 cells, shControl,
- GSM7025199 PANC-1 cells, shPin1#1, biological replicate 1 PANC-1 cells, shPin1#1,
- GSM7025200 PANC-1 cells, shPin1#1, biological replicate 2 PANC-1 cells, shPin1#1,
- GSM7025201 PANC-1 cells, shPin1#1, biological replicate 3 PANC-1 cells, shPin1#1,
- GSM7025202 PANC-1 cells, shPin1#2, biological replicate 1 PANC-1 cells, shPin1#2,
- GSM7025203 PANC-1 cells, shPin1#2, biological replicate 2 PANC-1 cells, shPin1#2,
- GSM7025204 PANC-1 cells, shPin1#2, biological replicate 3 PANC-1 cells, shPin1#2,
- GSM7025205 U2OS cells, shControl, biological replicate 1 U2OS cells, shControl,
- GSM7025206 U2OS cells, shControl, biological replicate 2 U2OS cells, shControl,
- GSM7025207 U2OS cells, shControl, biological replicate 3 U2OS cells, shControl,
- GSM7025208 U2OS cells, shPin1#1, biological replicate 1 U2OS cells, shPin1#1,
- GSM7025209 U2OS cells, shPin1#1, biological replicate 2 U2OS cells, shPin1#1,
- GSM7025210 U2OS cells, shPin1#1, biological replicate 3 U2OS cells, shPin1#1,
- GSM7025211 U2OS cells, shPin1#2, biological replicate 1 U2OS cells, shPin1#2,
- GSM7025212 U2OS cells, shPin1#2, biological replicate 2 U2OS cells, shPin1#2,
- GSM7025213 U2OS cells, shPin1#2, biological replicate 3 U2OS cells, shPin1#2,
- GSE179351 Radiation Therapy Inhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial 54 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE151580 Integrative transcriptomic characterization of matched primary and hepatic metastases of pancreatic ductal adenocarcinoma 33 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE288221 RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines 32 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE111672 Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas 23 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE150043 Deeper insight into Pancreatic Ductal Adenocarcinoma (PDAC) survival heterogeneity using integrative analyses of individual and global transcriptome based networks 19 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE135731 Genome-wide identification of circular RNAs with critical roles in pancreatic ductal adenocarcinoma 3 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE71729 Virtual Microdissection of Pancreatic Ductal Adenocarcinoma Reveals Tumor and Stroma Subtypes. 357 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE102238 Gene expression signatures associated with Perineural Invasion in pancreatic ductal adenocarcinoma 100 samples same disease briefing · shares adenocarcinoma, pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.