GEO series
Usp17l affects 2c gene transcription by regulating H2AK119ub
GSE224711
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
11 samples
2025/02/19
GPL24247
Summary
We found that H2AK119ub could regulate 2 cell genes, Usp17l could also activate 2c gene, and Usp17l could remove ubiquitination modification of H2AK119ub. Therefore, in order to determine whether Usp17l affects 2c gene transcription by regulating H2AK119ub, we knockdown Usp17l. The enrichment of H2AK119ub/H3K27me3 was detected by CUT&Tag . We also sorted out Zscan4 positive and negative cells, and detected the concentration of H3K27me3 by cut-tag
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Paper (PMID 40750602) ↗
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