NAT10-mediated ac4C modification promotes neuroectoderm specification of human embryonic stem cells via acetylating NR2F1 mRNA to enhance translation efficiency
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE225052_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA933615 and SRA study SRP422552. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7037984 ESC-1.Input
- GSM7037985 ESC-1.IP
- GSM7037986 ESC-2.Input
- GSM7037987 ESC-2.IP
- GSM7037988 ME-1.Input
- GSM7037989 ME-1.IP
- GSM7037990 ME-2.Input
- GSM7037991 ME-2.IP
- GSM7037992 NEP-1.Input
- GSM7037993 NEP-1.IP
- GSM7037994 NEP-2.Input
- GSM7037995 NEP-2.IP
- GSM7037996 hESC-1 RNA-seq
- GSM7037997 hESC-2 RNA-seq
- GSM7037998 NEP-1 RNA-seq
- GSM7037999 NEP-2 RNA-seq
- GSM7038000 ME-1 RNA-seq
- GSM7038001 ME-2 RNA-seq
- GSM7038002 hESC-1 Ribo-seq
- GSM7038003 hESC-2 Ribo-seq
- GSM7038004 NEP-1 Ribo-seq
- GSM7038005 NEP-2 Ribo-seq
- GSM7038006 ME-1 Ribo-seq
- GSM7038007 ME-2 Ribo-seq
- GSE225051 NAT10-mediated ac4C modification promotes neuroectoderm specification of human embryonic stem cells via acetylating NR2F1 mRNA to enhance translation efficiency [Ribo-seq] 6 samples shares nr2f1, ac4c, nat10-mediated, neuroectoderm, specification, modification, acetylating, translation
- GSE225050 NAT10-mediated ac4C modification promotes neuroectoderm specification of human embryonic stem cells via acetylating NR2F1 mRNA to enhance translation efficiency [RNA-seq] 6 samples shares nr2f1, ac4c, nat10-mediated, neuroectoderm, specification, modification, acetylating, translation
- GSE246506 NAT10-mediated mRNA N4-acetylcitidine (ac4C) Promotes Stemness and Leukemogenesis in Acute Myeloid Leukemia 26 samples shares ac4c, nat10-mediated
- GSE248476 Transcriptome-wide profiles and ac4c modification profile in RA FLS with NAT10 knockdown 18 samples shares ac4c, modification
- GSE314697 NAT10 drives head and neck squamous cell carcinoma proliferation via ac4C modification of DDIT4 mRNA 4 samples shares ac4c, modification
- GSE315121 NAT10-mediated ac4C RNA acetylation stabilizes CXCL5/DEK mRNA to drive proliferation and metastasis in lung adenocarcinoma [RNA-Seq] 2 samples shares ac4c, nat10-mediated
- GSE237543 Function and Mechanism of NAT10-mediated N4-acetylcytidine modification in osteosarcoma 16 samples shares nat10-mediated, modification
- GSE300796 NAT10-mediated N4-acetylcytidine modification promotes intrahepatic cholangiocarcinoma progression by suppressing transposable element expression via regulating chromatin remodeling [ATAC-seq] 8 samples shares nat10-mediated, modification
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.